Evolutionary Cell Biology

The vast majority of eukaryotic diversity and evolutionary innovation is found among protists. We are analysing the evolutionary relationships and progression of individual lineages in concert, which allows us to identify homologous cellular structures and key proteins using phylogenetic methods as a support. Key aspects, such as for example the evolution of protein targeting into organelles or the expansion of intermediate filament-like protein families in protists as a mean to evolve unique single-cell phenotypes and buffer external sheering forces, are in the focus of our combined analysis. Both of these topics have recently become important to understand the evolutionary dynamics of major eukaryotic groups.

Relevant Publications:

Gould SB, Garg SG, Martin WF: Bacterial vesicle secretion and the evolutionary origin of the eukaryotic endomembrane system. Trends in Microbiology ••:•••-••• (2016)

de Vries J, Stanton A, Archibald J, Gould SB: Streptophyte terrestrilisation in light of plastid evolution. Trends in Plant Science ••:•••-••• (2016)

Gould SB, Maier UG, BMartin WF: Protein import and the origin of red complex plastids. Curr Biol in press (2015)

de Vries J, Sousa FL, Bölter B, Soll J, Gould SB: YCF1: a green TIC? Plant Cell in press (2015)

Habicht J, Woehle C, Gould SB: Tetrahymena expresses more than a hundred proteins with lipid-binding MORN motifs that can differ in their sub cellular localisation. J Eukaryot Microbiol in press (2015)

Zimorski V, Ku C, Martin WF, Gould SB: Endosymbiotic theory for organelle origins. Curr Opin Microbiol 22:38-48 (2014). PDF

El-Haddad H, Pryzborski JM, Kraft LGK, McFadden GI, Waller RF, Gould SB: Characterization of TtALV2, an essential charged repeat motif protein of the Tetrahymena thermophila membrane skeleton. Eukaryot Cell (2013). PDF

Dagan T, Roettger M, Stucken K, Landan G, Koch R, Major P, Gould SB, Goremykin VV, Rippka R, Tandeau de Marsac N, Gugger M, Lockhart PJ, Allen JA, Brune I, Maus I, Pühler A, Martin WF: Genomes of stigonematalean cyanobacteria (subsection V) and the evolution of oxygenic photosynthesis from prokaryotes to plastids. GBE 5:31-44 (2013). PDF

Gould SB: Evolutionary genomics: Algae´s complex origins. Nature doi:10.1038/nature11759 (2012). PDF

Muller M, Mentel M, van Hellemond JJ, Henze K, Woehle C, Gould SB, Yu RY, van der Giezen M, Tielens AG, Martin W: Biochemistry and evolution of anaerobic energy metabolism in eukaryotes. Microbiol Mol Biol Rev 76:444-495 (2012).  PDF

Gould SB, Kraft LG, van Dooren GG, Goodman CD, Ford KL, Cassin AM, Bacic A, McFadden GI, Waller RF: Ciliate pellicular proteome identifies novel protein families with characteristic repeat motifs that are common to Alveolates. Mol Biol Evol 28 (3):1319-1331 (2011). PDF

Woehle C, Dagan T, Martin W, Gould SB: Red and Problematic Green Phylogenetic Signals among Thousands of Nuclear Genes from the Photosynthetic and Apicomplexa-Related Chromera velia. Genome Biol Evol 3:1220-30 (2011). PDF

Bullen HE, Tonkin CJ, O'Donnell RA, Tham WH, Papenfuss AT, Gould S, Cowman AF, Crabb BS, Gilson PR: A novel family of Apicomplexan glideosome-associated proteins with an inner membrane-anchoring role. J Biol Chem 284:25353-63 (2009). PDF

Gould SB, Waller RF, McFadden GI: Plastid evolution. 
Annu Rev Plant Biol 59:491-517 (2008). PDF

Baum J, Tonkin CJ, Paul AS, Rug M, Smith BJ, Gould SB, Richard D, Pollard TD, Cowman AF: A malaria parasite formin regulates actin polymerization and localizes to the parasite-erythrocyte moving junction during invasion. Cell Host Microbe 3:188-98 (2008). PDF

Gould SB, Tham WH, Cowman AF, McFadden GI, Waller RF: Alveolins, a new family of cortical proteins that define the protist infrakingdom Alveolata. Mol Biol Evol 25:1219-30 (2008). PDF

Gould SB: Ariadne's thread: Guiding a precursor protein across five membranes in a cryptophyte. J Phycol 44:23-26 (2008). PDF 

Sommer MS, Gould SB, Lehmann P, Gruber A, Przyborski JM, Maier UG: Der1-mediated preprotein import into the periplastid compartment of chromalveolates? Mol Biol Evol 24:918-28 (2007). PDF

Gruber A, Vugrinec S, Hempel F, Gould SB, Maier UG, Kroth PG: Protein targeting into complex diatom plastids: functional characterisation of a specific targeting motif. Plant Mol Biol 64:519-30 (2007). PDF  

Gould SB, Fan E, Hempel F, Maier UG, Klosgen RB: Translocation of a phycoerythrin alpha subunit across five biological membranes. J Biol Chem 282:30295-302 (2007). PDF 
Gould SB, Sommer MS, Hadfi K, Zauner S, Kroth PG, Maier UG: Protein targeting into the complex plastid of cryptophytes. J Mol Evol 62:674-81 (2006). PDF  

Gould SB, Sommer MS, Kroth PG, Gile GH, Keeling PJ, Maier UG: Nucleus-to-nucleus gene transfer and protein retargeting into a remnant cytoplasm of cryptophytes and diatoms. Mol Biol Evol 23:2413-22 (2006). PDF  

Deschamps P, Haferkamp I, Dauvillee D, Haebel S, Steup M, Buleon A, Putaux JL, Colleoni C, d'Hulst C, Plancke C, Gould S, Maier U, Neuhaus HE, Ball S: Nature of the periplastidial pathway of starch synthesis in the cryptophyte Guillardia theta. Eukaryot Cell 5:954-63 (2006). PDF  

Responsible for the content: E-MailProf. Dr. William F. Martin